Photographs of the physical examination at the first visit (A-C) and at 441 days after oral fluralaner administration (DF). Erythema, alopecia, and erosion on the tail (A). Edema, erythema, and alopecia with fissures on the foot pad (B). Erythema, scales, and crusting on the ear pinna (C).|@|~(^,^)~|@|Photomicrographs of the skin biopsy. Accumulated Demodex canis (Yellow arrow) in a hair follicle of the left metatarsophalangeal region (A). Inflammatory cell infiltration in the dermis of the left ear tip (B).