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pISSN 1598-298X
eISSN 2384-0749
Ex) Article Title, Author, Keywords
J Vet Clin 2021; 38(2): 56-62
https://doi.org/10.17555/jvc.2021.04.38.2.56
Published online April 30, 2021
Woong-bin Ro1,*, Min-hee Kang1,*, Doo-won Song1,*, Heyong-seok Kim1,*, Ga-won Lee1,*, Hyun-min Kang1,*, Jong-won Kim1,*, Su-bin Park1,2,*, Jin-ha Jeon1,3,*, Jong-seon Keum1,4,*, Won-keun Park5,*, Jin Ko6,*, Sue-kyoung Sim7,*, Hyun-Jung Lee8,*, Hee-myung Park1,*
Copyright © The Korean Society of Veterinary Clinics.
Madecassoside, an active ingredient extracted from Centella asiatica, is used for treatment of various skin disorders in humans. However, the effect of madecassoside on the skin of dogs and cats has not been studied yet. The purpose of this study was to evaluate clinical efficacy of topical madecassoside cream in dogs and cats with skin diseases. A total of twenty-one dogs and ten cats with various skin diseases were included in the study. The 1% topical madecassoside cream was applied to the animal's skin lesion at least once a day for 7 days, and the skin condition was evaluated before the application of madecassoside cream (day 0) and 7 days after the application (day 7). The skin condition was scored by five clinical indices: canine atopic dermatitis extent and severity index-4 (CADESI-4), coat condition, pruritus, scale, and general condition. In dogs, all five clinical indices (CADESI-4, coat condition, pruritus, scale, and general condition) were significantly decreased on day 7 compared to those on day 0 (p < 0.0001, p < 0.05, p < 0.001, p < 0.01, and p < 0.05, respectively). In cats, the CADESI-4 and scale were significantly decreased on day 7 compared to those on day 0 (p < 0.01 and p < 0.05, respectively). No adverse effects were observed during the trial period in the dogs and cats included in this study. The results of this study demonstrate that the topical madecassoside cream is applicable to skin lesions in dogs and cats.
Keywords: madecassoside, topical cream, skin disease, dogs, cats
J Vet Clin 2021; 38(2): 56-62
Published online April 30, 2021 https://doi.org/10.17555/jvc.2021.04.38.2.56
Copyright © The Korean Society of Veterinary Clinics.
Woong-bin Ro1,*, Min-hee Kang1,*, Doo-won Song1,*, Heyong-seok Kim1,*, Ga-won Lee1,*, Hyun-min Kang1,*, Jong-won Kim1,*, Su-bin Park1,2,*, Jin-ha Jeon1,3,*, Jong-seon Keum1,4,*, Won-keun Park5,*, Jin Ko6,*, Sue-kyoung Sim7,*, Hyun-Jung Lee8,*, Hee-myung Park1,*
*Laboratory of Veterinary Internal Medicine, College of Veterinary Medicine, Konkuk University, Seoul 05029, Korea
**Haedeun Animal Medical Center, Yangju 11492, Korea
***Goodpapa Animal Medical Center, Seoul 07008, Korea
****Smart Animal Medical Center, Seoul 03461, Korea
*****Yonggang Animal Hospital, Seoul 04159, Korea
******Songjeong Animal Medical Center, Gwangju 12747, Korea
*******Jayeonen Animal Clinic, Suwon 16509, Korea
********Department of Animal, Veterinary and Food Sciences, University of Idaho, 875 Perimeter Dr., Moscow 83844, USA
Madecassoside, an active ingredient extracted from Centella asiatica, is used for treatment of various skin disorders in humans. However, the effect of madecassoside on the skin of dogs and cats has not been studied yet. The purpose of this study was to evaluate clinical efficacy of topical madecassoside cream in dogs and cats with skin diseases. A total of twenty-one dogs and ten cats with various skin diseases were included in the study. The 1% topical madecassoside cream was applied to the animal's skin lesion at least once a day for 7 days, and the skin condition was evaluated before the application of madecassoside cream (day 0) and 7 days after the application (day 7). The skin condition was scored by five clinical indices: canine atopic dermatitis extent and severity index-4 (CADESI-4), coat condition, pruritus, scale, and general condition. In dogs, all five clinical indices (CADESI-4, coat condition, pruritus, scale, and general condition) were significantly decreased on day 7 compared to those on day 0 (p < 0.0001, p < 0.05, p < 0.001, p < 0.01, and p < 0.05, respectively). In cats, the CADESI-4 and scale were significantly decreased on day 7 compared to those on day 0 (p < 0.01 and p < 0.05, respectively). No adverse effects were observed during the trial period in the dogs and cats included in this study. The results of this study demonstrate that the topical madecassoside cream is applicable to skin lesions in dogs and cats.
Keywords: madecassoside, topical cream, skin disease, dogs, cats
