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Article

J Vet Clin 2015; 32(6): 491-498

https://doi.org/10.17555/jvc.2015.12.32.6.491

Published online December 31, 2015

The Effect of Doxapram on Cardiopulmonary Function in Dogs under Total Intravenous Anesthesia with Remifentanil and Propofol

Sungho Yun, Youngsam Kwon

Department of Veterinary Surgery, College of Veterinary Medicine, Kyungpook National University, Daegu 702-701, Republic of Korea

Copyright © The Korean Society of Veterinary Clinics.

Abstract

We investigated the effect of constant rate infusion (CRI) with doxapram on cardiopulmonary function during total intravenous anesthesia (TIVA) with remifentanil and propofol CRI in dogs. Fifteen male Beagle dogs were randomly divided into 3 groups. All groups were premedicated with medetomidine (20 μg/kg, IV) and anesthetized by remifentanil/propofol CRI for one and half hour. At the initiating of the anesthesia, different doses of doxapram for each group were administrated as the followings; D1 group - doxapram 0.25 mg/kg bolus followed by doxapram 8.33 μg/kg/min, D2 group - doxapram 2 mg/kg bolus followed by doxapram 66.66 μg/kg/min, control group - normal saline. The anesthetic depth for surgery was well maintained in all groups throughout the anesthetic periods. The respiratory rate was significantly higher in D2 group than that of control group (p < 0.05). The values of PaO₂ and SaO₂ were significantly increased in both D1 and D2 groups compared with control group (p < 0.05). High dose of doxapram (D2 group) significantly decreased the level of PaCO₂ compared with control group (p < 0.05). The values of systolic, mean and diastolic arterial pressure were significantly increased in doxapram 2 group (p < 0.05). There were no significant differences in the values of heart rate and pH of arterial blood. Therefore, doxapram CRI may be useful to alleviate the suppression of cardiopulmonary function including hypoxia and hypotension during TIVA with remifentanil and propofol in dogs.

Keywords: dog, doxapram, propofol, remifentanil, TIVA

Article

J Vet Clin 2015; 32(6): 491-498

Published online December 31, 2015 https://doi.org/10.17555/jvc.2015.12.32.6.491

Copyright © The Korean Society of Veterinary Clinics.

The Effect of Doxapram on Cardiopulmonary Function in Dogs under Total Intravenous Anesthesia with Remifentanil and Propofol

Sungho Yun, Youngsam Kwon

Department of Veterinary Surgery, College of Veterinary Medicine, Kyungpook National University, Daegu 702-701, Republic of Korea

Abstract

We investigated the effect of constant rate infusion (CRI) with doxapram on cardiopulmonary function during total intravenous anesthesia (TIVA) with remifentanil and propofol CRI in dogs. Fifteen male Beagle dogs were randomly divided into 3 groups. All groups were premedicated with medetomidine (20 μg/kg, IV) and anesthetized by remifentanil/propofol CRI for one and half hour. At the initiating of the anesthesia, different doses of doxapram for each group were administrated as the followings; D1 group - doxapram 0.25 mg/kg bolus followed by doxapram 8.33 μg/kg/min, D2 group - doxapram 2 mg/kg bolus followed by doxapram 66.66 μg/kg/min, control group - normal saline. The anesthetic depth for surgery was well maintained in all groups throughout the anesthetic periods. The respiratory rate was significantly higher in D2 group than that of control group (p < 0.05). The values of PaO₂ and SaO₂ were significantly increased in both D1 and D2 groups compared with control group (p < 0.05). High dose of doxapram (D2 group) significantly decreased the level of PaCO₂ compared with control group (p < 0.05). The values of systolic, mean and diastolic arterial pressure were significantly increased in doxapram 2 group (p < 0.05). There were no significant differences in the values of heart rate and pH of arterial blood. Therefore, doxapram CRI may be useful to alleviate the suppression of cardiopulmonary function including hypoxia and hypotension during TIVA with remifentanil and propofol in dogs.

Keywords: dog, doxapram, propofol, remifentanil, TIVA

Vol.41 No.2 April 2024

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The Korean Society of Veterinary Clinics

pISSN 1598-298X
eISSN 2384-0749

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