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J Vet Clin 2014; 31(3): 170-174

https://doi.org/10.17555/ksvc.2014.06.31.3.170

Published online June 1, 2014

Activation of Platelet Rich Plasma by Soluble Canine Small Intestinal Submucosa Gel and Bovine Thrombin

A-Jin Lee1, Changsun Lee1, Hyun Kim1, Dai-Jung Chung1, Sun Hee Do2, Hwi-Yool Kim1

*Departments of Veterinary Surgery, College of Veterinary Medicine, Konkuk University, Seoul 143-701, Korea
**Departments of Veterinary Clinical Pathology, College of Veterinary Medicine, Konkuk University, Seoul 143-701, Korea

Copyright © The Korean Society of Veterinary Clinics.

Abstract

This study evaluated the efficacy of soluble canine small intestinal submucosa gel in comparison to bovine thrombin in activating rabbit platelet rich plasma (PRP) by detecting growth factors. PRP from rabbits was activated by using soluble canine SIS gel, bovine thrombin, or both. The surface morphology of each group of samples was examined by scanning electron microscopy. The release of transforming growth factor (TGF)-${beta}1$ from each set of samples was measured over 7 days using enzyme-linked immunosorbent assay. The PRP-canine SIS gel group exhibited the highest total amount of released TGF-${beta}1$. However, there were no significant differences between any groups. The use of soluble type of canine SIS gel could be an effective alternative to bovine thrombin.

Keywords: PRP (platelet-rich plasma) activation, soluble canine SIS (Small Intestinal Submucosa) gel, bovine thrombin, growth factor.

Article

J Vet Clin 2014; 31(3): 170-174

Published online June 1, 2014 https://doi.org/10.17555/ksvc.2014.06.31.3.170

Copyright © The Korean Society of Veterinary Clinics.

Activation of Platelet Rich Plasma by Soluble Canine Small Intestinal Submucosa Gel and Bovine Thrombin

A-Jin Lee1, Changsun Lee1, Hyun Kim1, Dai-Jung Chung1, Sun Hee Do2, Hwi-Yool Kim1

*Departments of Veterinary Surgery, College of Veterinary Medicine, Konkuk University, Seoul 143-701, Korea
**Departments of Veterinary Clinical Pathology, College of Veterinary Medicine, Konkuk University, Seoul 143-701, Korea

Abstract

This study evaluated the efficacy of soluble canine small intestinal submucosa gel in comparison to bovine thrombin in activating rabbit platelet rich plasma (PRP) by detecting growth factors. PRP from rabbits was activated by using soluble canine SIS gel, bovine thrombin, or both. The surface morphology of each group of samples was examined by scanning electron microscopy. The release of transforming growth factor (TGF)-${beta}1$ from each set of samples was measured over 7 days using enzyme-linked immunosorbent assay. The PRP-canine SIS gel group exhibited the highest total amount of released TGF-${beta}1$. However, there were no significant differences between any groups. The use of soluble type of canine SIS gel could be an effective alternative to bovine thrombin.

Keywords: PRP (platelet-rich plasma) activation, soluble canine SIS (Small Intestinal Submucosa) gel, bovine thrombin, growth factor.

Vol.39 No.4 August, 2022

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The Korean Society of Veterinary Clinics

pISSN 1598-298X
eISSN 2384-0749

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