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Article

J Vet Clin 2016; 33(6): 332-339

https://doi.org/10.17555/jvc.2016.12.33.6.332

Published online December 31, 2016

Evaluation of Bilayer Polycaprolactone Scaffold for Osteochondral Regeneration in Rabbits

Min-hyeok Park1, Ya-won Hwang1, Do-Sun Jeong2, Gon-hyung Kim1

1Laboratory of Veterinary Surgery, Veterinary Medical Center, College of Veterinary Medicine, Chungbuk National University, 2TE-Bios Company, LTD, C&V Center

Copyright © The Korean Society of Veterinary Clinics.

Abstract

Polycaprolactone (PCL) scaffold have been developed as an alternative to natural donor tissue to repair a large osteochondral defect. The objective of this study is to evaluate efficacy and biocompatibility of bilayer PCL scaffold implanted for osteochondral repair in rabbit. Twenty-two male New Zealand White rabbits were used in this animal experiment. Rabbits were divided into three groups. Experimental surgery was carried out under general anesthesia. Osteochondral defects (5 mm diameter and 5 mm deep) were made in the center of the patellar groove using a 5 mm diameter biopsy punch. In group I (3D plotting) and group II (salt-leaching), the scaffold was implanted using the press-fitted technique into the defect. In control group, after osteochondral defect was created, the defect was left without implant. After four and eight weeks, rabbits were sacrificed and the defects were evaluated by macro -and microscopical methods. There were not found animal death and severe inflammatory evidence during the experimental periods. There were no significant differences between the experimental groups in gross evaluation. However the group I scored significantly higher than group II at 8 weeks in histological evaluation (P < 0.05). The 3-D plotting PCL scaffold was more suitable method for reconstruction of osteochondral defect than a salt-leaching PCL scaffold.

Keywords: Osteochondral defect, Osteochondral repair, PCL scaffold, Rabbit

Article

J Vet Clin 2016; 33(6): 332-339

Published online December 31, 2016 https://doi.org/10.17555/jvc.2016.12.33.6.332

Copyright © The Korean Society of Veterinary Clinics.

Evaluation of Bilayer Polycaprolactone Scaffold for Osteochondral Regeneration in Rabbits

Min-hyeok Park1, Ya-won Hwang1, Do-Sun Jeong2, Gon-hyung Kim1

1Laboratory of Veterinary Surgery, Veterinary Medical Center, College of Veterinary Medicine, Chungbuk National University, 2TE-Bios Company, LTD, C&V Center

Abstract

Polycaprolactone (PCL) scaffold have been developed as an alternative to natural donor tissue to repair a large osteochondral defect. The objective of this study is to evaluate efficacy and biocompatibility of bilayer PCL scaffold implanted for osteochondral repair in rabbit. Twenty-two male New Zealand White rabbits were used in this animal experiment. Rabbits were divided into three groups. Experimental surgery was carried out under general anesthesia. Osteochondral defects (5 mm diameter and 5 mm deep) were made in the center of the patellar groove using a 5 mm diameter biopsy punch. In group I (3D plotting) and group II (salt-leaching), the scaffold was implanted using the press-fitted technique into the defect. In control group, after osteochondral defect was created, the defect was left without implant. After four and eight weeks, rabbits were sacrificed and the defects were evaluated by macro -and microscopical methods. There were not found animal death and severe inflammatory evidence during the experimental periods. There were no significant differences between the experimental groups in gross evaluation. However the group I scored significantly higher than group II at 8 weeks in histological evaluation (P < 0.05). The 3-D plotting PCL scaffold was more suitable method for reconstruction of osteochondral defect than a salt-leaching PCL scaffold.

Keywords: Osteochondral defect, Osteochondral repair, PCL scaffold, Rabbit

Vol.41 No.2 April 2024

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The Korean Society of Veterinary Clinics

pISSN 1598-298X
eISSN 2384-0749

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