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Article

J Vet Clin 2020; 37(1): 38-41

https://doi.org/10.17555/jvc.2020.02.37.1.38

Published online February 29, 2020

Histopathologic Characteristics of Canine Desmoplastic Melanoma

Preeti Kumari Chaudhary, Yeon Chae, Soochong Kim

Department of Veterinary Medicine and Veterinary Medical Center, College of Veterinary Medicine, Chungbuk National University, Cheongju 28644, Korea

Copyright © The Korean Society of Veterinary Clinics.

Abstract

An 11-year-old castrated male miniature Schnauzer, weighing 8 kg, presented with multiple masses on the humeri. Grossly, the masses were separated from the surrounding soft tissues. Desmoplastic melanoma is an uncommon tumor in dogs. Fine-needle aspiration cytology showed large spindle-shaped cells with a high nuclear-cytoplasmic ratio. Histopathology showed interlacing bundles of fibroblast-like cells, highly pleomorphic multinuclear cells, occasional atypical spindle cells separated by fibrocollagenous stroma, and lymphocyte aggregates admixed with abundant collagen. The tumors were diffusely positive for S100a, a strong marker for desmoplastic melanoma, and negative for desmin. Herein, we report the pathobiology of a rare, uncommon variant of melanoma in a dog.

Keywords: desmoplastic melanoma, dog, immunohistochemistry, pathology, S100a

Article

J Vet Clin 2020; 37(1): 38-41

Published online February 29, 2020 https://doi.org/10.17555/jvc.2020.02.37.1.38

Copyright © The Korean Society of Veterinary Clinics.

Histopathologic Characteristics of Canine Desmoplastic Melanoma

Preeti Kumari Chaudhary, Yeon Chae, Soochong Kim

Department of Veterinary Medicine and Veterinary Medical Center, College of Veterinary Medicine, Chungbuk National University, Cheongju 28644, Korea

Abstract

An 11-year-old castrated male miniature Schnauzer, weighing 8 kg, presented with multiple masses on the humeri. Grossly, the masses were separated from the surrounding soft tissues. Desmoplastic melanoma is an uncommon tumor in dogs. Fine-needle aspiration cytology showed large spindle-shaped cells with a high nuclear-cytoplasmic ratio. Histopathology showed interlacing bundles of fibroblast-like cells, highly pleomorphic multinuclear cells, occasional atypical spindle cells separated by fibrocollagenous stroma, and lymphocyte aggregates admixed with abundant collagen. The tumors were diffusely positive for S100a, a strong marker for desmoplastic melanoma, and negative for desmin. Herein, we report the pathobiology of a rare, uncommon variant of melanoma in a dog.

Keywords: desmoplastic melanoma, dog, immunohistochemistry, pathology, S100a

Vol.41 No.1 February 2024

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The Korean Society of Veterinary Clinics

pISSN 1598-298X
eISSN 2384-0749

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